Sialo-Xenoantigenic Glycobiology (Record no. 57421)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03831nam a22005535i 4500 |
| 001 - CONTROL NUMBER | |
| control field | 978-3-642-34094-9 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20200421112221.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 121116s2013 gw | s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| ISBN | 9783642340949 |
| -- | 978-3-642-34094-9 |
| 082 04 - CLASSIFICATION NUMBER | |
| Call Number | 610.28 |
| 100 1# - AUTHOR NAME | |
| Author | Song, Kwon-Ho. |
| 245 10 - TITLE STATEMENT | |
| Title | Sialo-Xenoantigenic Glycobiology |
| Sub Title | Molecular Glycobiology of Sialylglycan-Xenoantigenic Determinants in Pig to Human Xenotransplantation / |
| 300 ## - PHYSICAL DESCRIPTION | |
| Number of Pages | XVI, 64 p. |
| 490 1# - SERIES STATEMENT | |
| Series statement | Sungkyunkwan University Outstanding Research, |
| 505 0# - FORMATTED CONTENTS NOTE | |
| Remark 2 | Screening of pig glycosyltransferase genes related to xenoantigens and their masking -- Cloning and tissue specific expression of pcmah and its alternative transcripts -- Functional characterization of pCMAH in the synthesis of N-glycolylneuraminic acid as the xenoantigenic determinant in pig-to-human xenotransplantation -- Identification of two alternative promoters of the pig CMP-N-acetylneuraminic acid hydroxylase gene -- Screening for xenoantigenic determinants formed by sialyltransferases. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc | Carbohydrate antigens on glycoconjugates of mammalian cells play crucial roles in various biological processes and are epitopes recognized by the immune system, as glycobiology has hugely been progressed during the past two decades. The book focuses on sialic acid-based xenoantigenes. In pig to human xenotransplantation, exposure of pig organs to human blood results in hyper acute rejection (HAR), caused by differences in carbohydrate epitopes between human and pig vascular endothelia. Although Gal-antigen as major antigen was eliminated, the remaining non-Gal antigens are considered to be xenoantigens. Sialosyl-Tn or Hanganutziu-Deicher (HD), are non-Gal antigens specific to natural antibodies in human. To overcome rejection responses such as HAR, studies of genes involved in carbohydrate antigens, causing xenoantigenicity, are necessary. Knowledge of pig glycosyltransferases are also useful to apply to xenoantigen masking or identification of the xenoantigenic sialylglycan(s). In the first chapter the screening for pig glycosyltransferase genes for xenoantigens is presented. In the chapter II to IV the cloning, characterization, and investigation of the regulatory mechanism of the pig CMAH gene in NeuGc biosynthesis is shown. Lastly, the effects of an alteration of pig glycosylation patterns on human serum-mediated cytotoxicity, caused by human sialyltransferases including hST6GalNAc IV is presented. . |
| 700 1# - AUTHOR 2 | |
| Author 2 | Kim, Cheorl-Ho. |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | http://dx.doi.org/10.1007/978-3-642-34094-9 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | eBooks |
| 264 #1 - | |
| -- | Berlin, Heidelberg : |
| -- | Springer Berlin Heidelberg : |
| -- | Imprint: Springer, |
| -- | 2013. |
| 336 ## - | |
| -- | text |
| -- | txt |
| -- | rdacontent |
| 337 ## - | |
| -- | computer |
| -- | c |
| -- | rdamedia |
| 338 ## - | |
| -- | online resource |
| -- | cr |
| -- | rdacarrier |
| 347 ## - | |
| -- | text file |
| -- | |
| -- | rda |
| 650 #0 - SUBJECT ADDED ENTRY--SUBJECT 1 | |
| -- | Engineering. |
| 650 #0 - SUBJECT ADDED ENTRY--SUBJECT 1 | |
| -- | Human genetics. |
| 650 #0 - SUBJECT ADDED ENTRY--SUBJECT 1 | |
| -- | Molecular biology. |
| 650 #0 - SUBJECT ADDED ENTRY--SUBJECT 1 | |
| -- | Medical biochemistry. |
| 650 #0 - SUBJECT ADDED ENTRY--SUBJECT 1 | |
| -- | Biochemistry. |
| 650 #0 - SUBJECT ADDED ENTRY--SUBJECT 1 | |
| -- | Biomedical engineering. |
| 650 14 - SUBJECT ADDED ENTRY--SUBJECT 1 | |
| -- | Engineering. |
| 650 24 - SUBJECT ADDED ENTRY--SUBJECT 1 | |
| -- | Biomedical Engineering. |
| 650 24 - SUBJECT ADDED ENTRY--SUBJECT 1 | |
| -- | Molecular Medicine. |
| 650 24 - SUBJECT ADDED ENTRY--SUBJECT 1 | |
| -- | Human Genetics. |
| 650 24 - SUBJECT ADDED ENTRY--SUBJECT 1 | |
| -- | Medical Biochemistry. |
| 650 24 - SUBJECT ADDED ENTRY--SUBJECT 1 | |
| -- | Biochemistry, general. |
| 830 #0 - SERIES ADDED ENTRY--UNIFORM TITLE | |
| -- | 2195-3546 ; |
| 912 ## - | |
| -- | ZDB-2-ENG |
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