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Cover; Title Page; Copyright; Contents; Preface; Chapter 1 Strategies to Bring Conjugated Polymers into Aqueous Media; 1.1 Introduction; 1.2 Synthesis of CPEs; 1.2.1 Anionic CPEs; 1.2.1.1 Sulfonated CPEs; 1.2.1.2 Carboxylated CPEs; 1.2.1.3 Phosphonated CPEs; 1.2.2 Cationic CPEs; 1.2.2.1 Ammonium CPEs; 1.2.2.2 Pyridinium CPEs; 1.2.2.3 Phosphonium CPEs; 1.2.3 Zwitterionic CPEs; 1.3 Neutral WSCPs; 1.4 Fabrication of CPNPs; 1.4.1 Reprecipitation; 1.4.2 Miniemulsion; 1.4.3 Nanoprecipitation; 1.5 Conclusion; References; Chapter 2 Direct Synthesis of Conjugated Polymer Nanoparticles.

2.1 Introduction2.2 Generation of CPNs; 2.2.1 Postpolymerization Techniques; 2.2.1.1 Nanoprecipitation; 2.2.1.2 Miniemulsification; 2.2.1.3 Microfluidics; 2.2.1.4 Self-Assembly; 2.2.2 Direct Polymerization in Heterogeneous Systems; 2.2.2.1 Emulsion Polymerization; 2.2.2.2 Polymerization in Miniemulsion; 2.2.2.3 Polymerization in Microemulsion; 2.2.2.4 Dispersion Polymerization; 2.3 Conclusion; References; Chapter 3 Conjugated Polymer Nanoparticles and Semiconducting Polymer Dots for Molecular Sensing and In Vivo and Cellular Imaging; 3.1 Introduction.

3.2 Preparation, Characterization, and Functionalization3.2.1 Preparation; 3.2.2 Characterization; 3.2.3 Functionalization; 3.3 Molecular Sensing; 3.3.1 Metal-Ion Sensing; 3.3.2 Oxygen and Reactive Oxygen Species Detection; 3.3.3 pH and Temperature Monitoring; 3.3.4 Sensing of Other Molecules; 3.4 Cellular Imaging; 3.4.1 Fluorescence Imaging; 3.4.1.1 In Vitro Imaging; 3.4.1.2 In Vivo Imaging; 3.4.2 Photoacoustic Imaging; 3.4.3 Multimodality Imaging; 3.5 Conclusion; Acknowledgment; References; Chapter 4 Conjugated Polymers for In Vivo Fluorescence Imaging; 4.1 Introduction.

4.2 In Vivo Fluorescence Imaging of Tumors4.3 Stimuli-Responsive Fluorescence Imaging; 4.4 In Vivo Fluorescence Cell Tracking; 4.5 Two-Photon Excited Brain Vascular Imaging; 4.6 Dual-Modality Imaging of Tumors In Vivo; 4.7 Other In Vivo Fluorescence Imaging Applications; 4.8 Conclusions and Perspectives; References; Chapter 5 Ï#x80;-Conjugated/Semiconducting Polymer Nanoparticles for Photoacoustic Imaging; 5.1 Introduction; 5.2 Mechanism of PA Imaging; 5.3 SPNs for PA Imaging; 5.3.1 Preparation of SPNs; 5.3.2 PA Imaging of Brain Vasculature; 5.3.3 PA Imaging of Tumor.

5.3.4 PA Imaging of Lymph Nodes5.3.5 PA Imaging of ROS; 5.3.6 Multimodal Imaging; 5.4 Summary and Outlook; References; Chapter 6 Conjugated Polymers for Two-Photon Live Cell Imaging; 6.1 Introduction; 6.2 Conjugated Polymers and CPNs as One-Photon Excitation Imaging Contrast Agents; 6.3 Conjugated Polymers as 2PEM Contrast Agents; 6.4 Conjugated-Polymer-Based Nanoparticles (CPNs) as 2PEM Contrast Agents; 6.4.1 CPNs Prepared from Hydrophobic Conjugated Polymers; 6.4.2 CPNs Prepared from Conjugated Polyelectrolytes (CPEs); 6.4.3 CPNs Prepared by Hybrid Materials.

This first book to specifically focus on applications of conjugated polymers in the fields of biology and biomedicine covers materials science, physical principles, and nanotechnology. The editor and authors, all pioneers and experts with extensive research experience in the field, firstly introduce the synthesis and optical properties of various conjugated polymers, highlighting how to make organic soluble polymers compatible with the aqueous environment. This is followed by the application of these materials in optical sensing and imaging as well as the emerging applications in image-guided therapy and in the treatment of neurodegenerative diseases. The result is a consolidated overview for polymer chemists, materials scientists, biochemists, biotechnologists, and bioengineers.