Online resource; title from PDF title page (EBSCO, viewed July 1, 2020).

Handbook of Biomaterials Biocompatibility is a systematic reference on host response to different biomaterials, taking into account their physical, mechanical and chemical properties. The book reviews recent progress in the design and study of biomaterials biocompatibility, along with current understanding on how to control immune system response. Sections provide the fundamental theories and challenges of biomaterials biocompatibility, the role of different biomaterials physicochemical surface properties on cell responses, cell responses to different physicochemical properties of polymers, ceramics, metals, carbons and nanomaterials, and biomaterials in different tissues, such as the cardiac, nervous system, cartilage and bone. This resource will be suitable for those working in the fields of materials science, regenerative engineering, medicine, medical devices and nanotechnology.

Front Cover -- Handbook of Biomaterials Biocompatibility -- Copyright Page -- Contents -- List of Contributors -- Preface -- Acknowledgments -- I. An introduction to biocompatibility -- 1 Principles of biocompatibility -- 1.1 Introduction -- 1.2 Conclusion -- References -- Further reading -- 2 Bacterial cell-biomaterials interactions -- 2.1 Introduction -- 2.2 Theoretical theories of bacterial adhesion to biomaterial surfaces -- 2.3 Factors influencing bacterial adhesion to biomaterial surfaces -- 2.3.1 Biomaterial surface properties -- 2.3.2 Plasma proteins -- 2.3.3 Platelets

2.3.4 Fluid flow -- 2.4 Bacterial interaction with antibacterial biomaterial surfaces -- 2.5 Signaling molecules in the regulation of bacterial adhesion on biomaterial surfaces -- 2.6 Summary and perspectives -- References -- 3 Macrophage response to biomaterials -- 3.1 The macrophage -- 3.2 Macrophage plasticity and polarization -- 3.3 The macrophage response to biomaterials -- 3.4 The macrophages and the development of immunomodulatory biomaterials -- 3.4.1 Immunomodulatory biomaterials -- 3.4.2 Macrophages in immunomodulation -- References -- 4 Dendritic cells responses to biomaterials

4.1 Introduction -- 4.2 Natural polymer biomaterials -- 4.3 Gelatin -- 4.4 Alginate -- 4.5 Chitosan -- 4.6 Synthetic polymer biomaterials -- 4.7 Poly(lactic-co-glycolic acid) -- 4.8 Polyethylene glycol -- 4.9 Blends -- 4.10 Poly(lactic-co-glycolic acid)-chitosan -- 4.10.1 Monomethoxy poly(ethylene glycol)-poly(lactic-co-glycolic acid) -- 4.11 Conclusion and future directions -- References -- 5 Impact of biomaterials' physical properties on cellular and molecular responses -- Abbreviations -- 5.1 Introduction -- 5.2 Cellular and molecular response following implantation

5.2.1 Blood-materials interaction -- 5.2.2 Acute inflammation -- 5.2.3 Chronic inflammation -- 5.2.4 Wound healing -- 5.2.5 Foreign body reaction -- 5.2.6 Fibrous capsule formation -- 5.3 Impact of physical properties on modulation of the host response -- 5.3.1 Size -- 5.3.2 Configuration and topography -- 5.3.3 Stiffness -- 5.3.4 Surface chemistry -- 5.4 Conclusion -- References -- 6 Impact of biomaterial mechanics on cellular and molecular responses -- 6.1 Introduction -- 6.2 Host response-biomaterial interplay -- 6.2.1 Phase I -- 6.2.2 Phase II -- 6.2.3 Phase III -- 6.2.4 Phase IV

6.2.5 Phase V -- 6.3 Other significant players of the foreign body reaction -- 6.4 Impact of biomaterial surface characteristics on the sequential phases of host response -- 6.4.1 On protein adsorption -- 6.4.2 On acute inflammation -- 6.4.3 On chronic inflammation -- 6.4.4 On foreign body giant cell formation -- 6.4.5 On capsule formation and fibrosis -- 6.5 Conclusion -- Conflict of interest -- References -- 7 Cell-biomaterials interactions: the role of growth factors -- 7.1 Introduction -- 7.2 What are growth factors? -- 7.3 Growth factors in bone tissue engineering