The brain-bladder axis in tissue growth and remodelling / Roustem N. Miftahof and Christian J. Cyron.
By: Miftahof, Roustem N [author.]
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Contributor(s): Cyron, Christian J [author.] | Institute of Physics (Great Britain) [publisher.].
Material type: 
BookSeries: IOP (Series)Release 21: ; IPEM-IOP series in physics and engineering in medicine and biology: ; IOP ebooks2021 collection: Publisher: Bristol [England] (Temple Circus, Temple Way, Bristol BS1 6HG, UK) : IOP Publishing, [2021]Description: 1 online resource (various pagings) : illustrations (some color).Content type: text Media type: electronic Carrier type: online resourceISBN: 9780750335676; 9780750335669.Subject(s): Bladder -- Growth -- Mathematical models | Bladder -- Innervation -- Mathematical models | Tissue remodeling -- Mathematical models | Neurobiology | Urinary Bladder -- physiology | Urinary Bladder -- innervation | Regeneration | Models, Theoretical | Neurobiology | Biomedical engineering | Medical physics and biophysicsAdditional physical formats: Print version:: No titleDDC classification: 612.4/673 Online resources: Click here to access online Also available in print."Version: 20210207"--Title page verso.
Includes bibliographical references.
1. Anatomical and morphological preliminaries -- 1.1. Overview of the urinary bladder -- 1.2. Detrusor muscle -- 1.3. 'Pacemakers' -- 1.4. Mechanosensation -- 1.5. Afferent signalling -- 1.6. Neuronal assemblies in the hypothalamus and adenohypophysis
2. Continual models of the bladder tissue -- 2.1. Single-phase models -- 2.2. Multiphase models
3. Models of the urinary bladder -- 3.1. The bladder as shell structure -- 3.2. The bladder as soft bioshell
4. Signalling mechanisms -- 4.1. L-Glutamate -- 4.2. GABA -- 4.3. Glycine -- 4.4. Somatostatin -- 4.5. Growth hormone releasing hormone -- 4.6. Ghrelin -- 4.7. Growth hormone -- 4.8. Insulin-like growth factor-1 -- 4.9. Myogenesis -- 4.10. Collagenesis
5. Modelling the (intra)hypothalamic-pituitary axis -- 5.1. Signal transduction -- 5.2. Protein-tyrosine kinase receptor signalling -- 5.3. Gene expression -- 5.4. Hormonal interactions
6. Growth and remodelling -- 6.1. Biological preliminaries -- 6.2. Continuum mechanics growth and remodelling models
7. Brain-bladder axis in tissue growth and remodelling -- 7.1. The architecture of the BBA -- 7.2. Mathematical formulation of the BBA -- 7.3. An Achilles' heel -- 7.4. Simulation results
8. What is to follow? -- 8.1. Making a model reliable -- 8.2. Model expansions in biomedicine -- 8.3. Implementations in engineering.
Applying the general deterministic approach of systems computational biology, the monograph considers questions related to the biomechanics of the human urinary bladder in conjunction with the peripheral and central nervous systems. The step-by-step development of mathematical models of separate structural elements and their assembly into a unique self-regulatory system offers, for the first time, a holistic overview and allows the investigation of the dynamics of the lower urinary tract system at its hierarchical levels. This book provides a coherent description and explanation for intertwined intracellular pathways in terms of spatiotemporal, whole body, tractable representations which are supported by numerous computational simulations.
Academic, Research and Industrial Scientists. The prerequisites to the book are a familiarity with the basic principles of cell and molecular biology, biochemistry and the mechanics of solids.
Also available in print.
Mode of access: World Wide Web.
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Prof. Dr. R.N. Miftahoft is a Professor Emeritus of applied mathematics and medicine. He is internationally acclaimed as a leading scientist in the field of computational systems biology. He has authored and co-authored seven books in the field. Prof. Dr-Ing. C.J. Cyron is a Full Professor at Hamburg University of Technology and has actively participated in the organization of a host of conferences, workshops and summer schools on biomechanics and mechanobiology over a number of years.
Title from PDF title page (viewed on August 5, 2021).
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