Evolution -- On the Comparison of Bacteriophage Populations -- Syntenic Dimensions of Genomic Evolution -- Phylogenetics -- Fast and Accurate Branch Support Calculation for Distance-based Phylogenetic Placements -- The Sackin Index of Simplex Networks -- Phylogenetic Placement Problem: A Hyperbolic Embedding Approach -- Phylogenetic Network Dissimilarity Measures That Take Branch Lengths Into Account -- Homology and Reconciliation -- The Complexity of Finding Common Partitions of Genomes with Predefined Block Sizes -- Reconciliation with Segmental Duplication, Transfer, Loss and Gain -- Quantifying Hierarchical Conflicts in Homology Statements -- On Partial Gene Transfer and its Impact on Gene Tree Reconstruction -- Genome Rearrangements -- Sorting by k-Cuts on Signed Permutations -- A New Approach for the Reversal Distance with Indels and Moves in Intergenic Regions -- Chromothripsis Rearrangements Are Informed by 3D Genome Organization -- Metagenomics -- Using Computational Synthetic Biology Toolsto Modulate Gene Expression within a Microbiome -- Metagenomics Binning of Long Reads Using Read-Overlap Graphs -- A Mixed Integer Linear Programming Algorithm for Plasmid Binning -- Genomic Sequencing -- Benchmarking Penalized Regression Methods in Machine Learning for Single Cell RNA Sequencing Data -- Deciphering the Tissue-speci c Regulatory Role of Intronless Genes Across Cancers.

This book constitutes the refereed proceedings of the 19th Annual RECOMB Satellite Workshop on Comparative Genomics, RECOMB-CG which took place in La Jolla, USA, during May 20-21, 2022. The 18 full papers included in this book were carefully reviewed and selected from 28 submissions. The papers were organized in topical sections on evolution; phylogenetics; homology and reconciliation; genome rearrangements; metagenomics; and genomic sequencing. .