000 04561nam a22005295i 4500
001 978-3-319-29328-8
003 DE-He213
005 20200420220213.0
007 cr nn 008mamaa
008 160323s2016 gw | s |||| 0|eng d
020 _a9783319293288
_9978-3-319-29328-8
024 7 _a10.1007/978-3-319-29328-8
_2doi
050 4 _aR856-857
072 7 _aMQW
_2bicssc
072 7 _aTEC009000
_2bisacsh
082 0 4 _a610.28
_223
245 1 0 _aMicrosystems for Enhanced Control of Cell Behavior
_h[electronic resource] :
_bFundamentals, Design and Manufacturing Strategies, Applications and Challenges /
_cedited by Andr�es D�iaz Lantada.
250 _a1st ed. 2016.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2016.
300 _aXVII, 454 p. 175 illus.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aStudies in Mechanobiology, Tissue Engineering and Biomaterials,
_x1868-2006 ;
_v18
505 0 _aSome introductory notes to cell behavior -- Brief introduction to the field of biomedical microsystems -- Brief introduction to bio-microsystems for interacting with cells -- Common bioengineering resources for interacting with cells -- Methodologies for the development of bio-microsystems -- Addressing the complexity of biomaterials by biomimetic CAD -- Multi-scale and multi-physical/biochemical modeling in bio-MEMS -- Rapid prototyping of bio-MEMS for interacting with cells -- Nanomanufacturing for biomedical MEMS -- Issues linked to the mass-production of biomedical microsystems -- Biomedical microsystems for disease management -- Overview of microsystems for studying cell behavior under culture -- Microsystems for studying cell adhesion, dynamics and and overall mechanobiology -- Smart microsystems for active cell culture toward relevant tissues -- Tissue engineering scaffolds for 3D cell culture -- Tissue engineering scaffolds for bone repair: General aspects -- Tissue engineering scaffolds for bone repair: Dental repair -- Tissue engineering scaffolds for repairing soft tissues -- Tissue engineering scaffolds for osteochondral repair -- From labs-on-chips to microfluidic cell culture -- Cell-based sensors and cell-based actuators -- Towards reliable organs-on-chips and humans-on-chips -- Towards effective and efficient biofabrication technologies -- Project-based learning in the field of biomedical microsystems -- Annexes.
520 _aThis handbook focuses on the entire development process of biomedical microsystems that promote special interactions with cells. Fundamentals of cell biology and mechanobiology are described as necessary preparatory input for design tasks. Advanced design, simulation, and micro/nanomanufacturing resources, whose combined use enables the development of biomedical microsystems capable of interacting at a cellular level, are covered in depth. A detailed series of chapters is then devoted to applications based on microsystems that offer enhanced cellular control, including microfluidic devices for diagnosis and therapy, cell-based sensors and actuators (smart biodevices), microstructured prostheses for improvement of biocompatibility, microstructured and microtextured cell culture matrices for promotion of cell growth and differentiation, electrophoretic microsystems for study of cell mechanics, microstructured and microtextured biodevices for study of cell adhesion and dynamics, and biomimetic microsystems (including organs-on-chips), among others. Challenges relating to the development of reliable in vitro biomimetic microsystems, the design and manufacture of complex geometries, and biofabrication are also discussed.
650 0 _aEngineering.
650 0 _aCell biology.
650 0 _aNanotechnology.
650 0 _aBiomedical engineering.
650 0 _aBiomaterials.
650 1 4 _aEngineering.
650 2 4 _aBiomedical Engineering.
650 2 4 _aBiomaterials.
650 2 4 _aCell Biology.
650 2 4 _aNanotechnology and Microengineering.
700 1 _aD�iaz Lantada, Andr�es.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783319293264
830 0 _aStudies in Mechanobiology, Tissue Engineering and Biomaterials,
_x1868-2006 ;
_v18
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-319-29328-8
912 _aZDB-2-ENG
942 _cEBK
999 _c51427
_d51427