000 04930nam a22006015i 4500
001 978-3-642-40193-0
003 DE-He213
005 20200421111203.0
007 cr nn 008mamaa
008 131223s2014 gw | s |||| 0|eng d
020 _a9783642401930
_9978-3-642-40193-0
024 7 _a10.1007/978-3-642-40193-0
_2doi
050 4 _aQA75.5-76.95
072 7 _aUY
_2bicssc
072 7 _aUYA
_2bicssc
072 7 _aCOM014000
_2bisacsh
072 7 _aCOM031000
_2bisacsh
082 0 4 _a004.0151
_223
245 1 0 _aDiscrete and Topological Models in Molecular Biology
_h[electronic resource] /
_cedited by Nataša Jonoska, Masahico Saito.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg :
_bImprint: Springer,
_c2014.
300 _aXIII, 524 p. 211 illus., 154 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aNatural Computing Series,
_x1619-7127
505 0 _aChap. 1 - Perspectives in Computational Genome Analysis -- Chap. 2 - The Sequence Reconstruction Problem -- Chap. 3 - Extracting Coevolving Characters from a Tree of Species -- Chap. 4 - When and How the Perfect Phylogeny Model Explains Evolution -- Chap. 5 - An Invitation to the Study of Brain Networks with Some Statistical Analysis of Thresholding Techniques -- Chap. 6 - Simplicial Models and Topological Inference in Biological Systems -- Chap. 7 - Combinatorial Insights into RNA Secondary Structure -- Chap. 8 - Redundant and Critical Noncovalent Interactions in Protein Rigid Cluster Analysis -- Chap. 9 - Modeling Autonomous Supramolecular Assembly -- Chap. 10 - The Role of Symmetry in Conformational Changes of Viral Capsids: A Mathematical Approach -- Chap. 11 - Minimal Tile and Bond-Edge Types for Self-Assembling DNA Graphs -- Chap. 12 - Programmed Genome Processing in Ciliates -- Chap. 13 - The Algebra of Gene Assembly in Ciliates -- Chap. 14 - Invariants of Graphs Modeling Nucleotide Rearrangements -- Chap. 15 - Introduction to DNA Topology -- Chap. 16 - Reactions Mediated by Topoisomerases and Other Enzymes: Modelling Localised DNA Transformations -- Chap. 17 - Site-Specific Recombination on Unknot and Unlink Substrates Producing Two-Bridge Links -- Chap. 18 - Site-Specific Recombination Modeled as a Band Surgery: Applications to Xer Recombination -- Chap. 19 - Understanding DNA Looping Through Cre-Recombination Kinetics -- Chap. 20 - The QSSA in Chemical Kinetics: As taught and as Practiced -- Chap. 21 - Algebraic Models and Their Use in Systems Biology -- Chap. 22 - Deconstructing Complex Nonlinear Models in System Design Space -- Chap. 23 - IBCell Morphocharts: A Computational Model for Linking Cell Molecular Activity with Emerging Tissue Morphology.
520 _aTheoretical tools and insights from discrete mathematics, theoretical computer science, and topology now play essential roles in our understanding of vital biomolecular processes. The related methods are now employed in various fields of mathematical biology as instruments to "zoom in" on processes at a molec­ular level.  This book contains expository chapters on how contemporary models from discrete mathematics - in do­mains such as algebra, combinatorics, and graph and knot theories - can provide perspective on biomolecular problems ranging from data analysis, molecular and gene arrangements and structures, and knotted DNA embeddings via spatial graph models to the dynamics and kinetics of molecular interactions.  The contributing authors are among the leading scientists in this field and the book is a reference for re­searchers in mathematics and theoretical computer science who are engaged with modeling molecular and biological phenomena using discrete methods. It may also serve as a guide and supplement for graduate courses in mathematical biology or bioinformatics, introducing nontraditional aspects of mathematical biology.
650 0 _aComputer science.
650 0 _aComputers.
650 0 _aSystems biology.
650 0 _aCell biology.
650 0 _aEvolutionary biology.
650 0 _aBiomathematics.
650 0 _aBiological systems.
650 1 4 _aComputer Science.
650 2 4 _aTheory of Computation.
650 2 4 _aMathematical and Computational Biology.
650 2 4 _aEvolutionary Biology.
650 2 4 _aSystems Biology.
650 2 4 _aCell Biology.
650 2 4 _aBiological Networks, Systems Biology.
700 1 _aJonoska, Nataša.
_eeditor.
700 1 _aSaito, Masahico.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783642401923
830 0 _aNatural Computing Series,
_x1619-7127
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-642-40193-0
912 _aZDB-2-SCS
942 _cEBK
999 _c53935
_d53935