000 04279nam a22005175i 4500
001 978-3-319-09336-9
003 DE-He213
005 20200421111652.0
007 cr nn 008mamaa
008 141018s2015 gw | s |||| 0|eng d
020 _a9783319093369
_9978-3-319-09336-9
024 7 _a10.1007/978-3-319-09336-9
_2doi
050 4 _aR856-857
072 7 _aMQW
_2bicssc
072 7 _aTEC009000
_2bisacsh
082 0 4 _a610.28
_223
245 1 4 _aThe Mechanobiology of Obesity and Related Diseases
_h[electronic resource] /
_cedited by Amit Gefen, Dafna Benayahu.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2015.
300 _aX, 296 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aStudies in Mechanobiology, Tissue Engineering and Biomaterials,
_x1868-2006 ;
_v16
505 0 _aMechanical behavior and properties of adipose tissue -- Mathematical models of adipose tissue dynamics -- Mechanical stretching and signaling pathways in adipogenesis- Role of mechanical stimulations in directing mesenchymal stem cell adipogenesis -- The vicious cycle of estrogen consumption and obesity: The role of mechanotransduction -- Extracellular matrix remodeling and mechanical stresses as modulators of adipose tissue metabolism and inflammation -- The Impact of Obesity and Weight Loss on Gait in Adults -- Excessive Weight Bearing Compromises Foot Structure and Function across the Lifespan -- Obesity, Osteoarthritis and Aging: The Biomechanical Links -- Impaired neutrophil mechanoregulation by fluid flow: A potential contributing factor for microvascular dysfunction in obesity -- Mechanotransduction and the myogenic response in diabetes -- Role of adipose cells in tumor microenvironment.
520 _aThis volume describes the state-of-knowledge in the study of the relationships between mechanical loading states in tissues and common pathophysiologies related to increase in mass of adipose tissues and/or hyperglycemia which eventually lead to obesity, diabetes, insulin resistance, hyperlipidemia, metabolic inflammations, certain types of cancer and other related diseases. There appears to be an interaction between the loading states in tissues and cells and these chronic conditions, as well as with factors such as age, gender and genetics of the individual. Bioengineering has made key contributions to this research field in providing technologies for cell biomechanics experimentation, microscopy and image processing, tissue engineering and multi-scale, multi-physics computational modeling. Topics at the frontier of this field of study include: the continuous monitoring of cell growth, proliferation and differentiation in response to mechanical factors such as stiffness of the extracellular matrix (ECM) and mechanical loads transferred through the ECM; mechanically-activated signaling pathways and molecular mechanisms; effects of different loading regimes and mechanical environments on differentiation fates of mesenchymal stem cells (MSCs) into myogenic and osteogenic versus adipogenic lineages; the interactions between nutrition and mechanotransduction; cell morphology, focal adhesion patterns and cytoskeletal remodeling changes in adipogenesis; activation of receptors related to diabetes by mechanical forces; brown and white adipose plasticity and its regulation by mechanical factors.
650 0 _aEngineering.
650 0 _aCell physiology.
650 0 _aBiomedical engineering.
650 0 _aBiomaterials.
650 1 4 _aEngineering.
650 2 4 _aBiomedical Engineering.
650 2 4 _aCell Physiology.
650 2 4 _aBiological and Medical Physics, Biophysics.
650 2 4 _aBiomaterials.
700 1 _aGefen, Amit.
_eeditor.
700 1 _aBenayahu, Dafna.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783319093352
830 0 _aStudies in Mechanobiology, Tissue Engineering and Biomaterials,
_x1868-2006 ;
_v16
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-319-09336-9
912 _aZDB-2-ENG
942 _cEBK
999 _c54462
_d54462