000			03344nam a22005295i 4500
001			978-3-319-07082-7
003			DE-He213
005			20200421112227.0
007			cr nn 008mamaa
008			140520s2014 gw | s |||| 0|eng d
020			_a9783319070827 _9978-3-319-07082-7
024	7		_a10.1007/978-3-319-07082-7 _2doi
050		4	_aQ342
072		7	_aUYQ _2bicssc
072		7	_aCOM004000 _2bisacsh
082	0	4	_a006.3 _223
100	1		_aJens, Marvin. _eauthor.
245	1	0	_aDissecting Regulatory Interactions of RNA and Protein _h[electronic resource] : _bCombining Computation and High-throughput Experiments in Systems Biology / _cby Marvin Jens.
264		1	_aCham : _bSpringer International Publishing : _bImprint: Springer, _c2014.
300			_aXVIII, 99 p. 38 illus., 19 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aSpringer Theses, Recognizing Outstanding Ph.D. Research, _x2190-5053
505	0		_aIntroduction -- Computational analysis of PAR-CLIP data -- Transcriptome-wide analysis of regulatory interactions of the RNA-binding protein HuR -- Binding site occupancy with competition interactions in equilibrium -- Circular RNAs are a large class of animal RNAs with regulatory potency -- Discussion -- Methods.
520			_aThe work described in this book is an excellent example of interdisciplinary research in systems biology. It shows how concepts and approaches from the field of physics can be efficiently used to answer biological questions, and reports on a novel methodology involving creative computer-based analyses of high-throughput biological data. Many of the findings described in the book, which are the result of collaborations between the author (a theoretical scientist) and experimental biologists, and between different laboratories, have been published in high-quality peer-reviewed journals such as Molecular Cell and Nature. However, while those publications address different aspects of post-transcriptional gene regulation, this book provides readers with a complete, coherent and logical view of the research project as a whole. The introduction presents post-transcriptional gene regulation from a distinct angle, highlighting aspects of information theory and evolution, and laying the groundwork for the questions addressed in the subsequent chapters, which concern the regulation of the transcriptome as the primary functional carrier of active genetic information.
650		0	_aEngineering.
650		0	_aGene expression.
650		0	_aBiochemistry.
650		0	_aSystems biology.
650		0	_aBiological systems.
650		0	_aComputational intelligence.
650	1	4	_aEngineering.
650	2	4	_aComputational Intelligence.
650	2	4	_aBiological Networks, Systems Biology.
650	2	4	_aGene Expression.
650	2	4	_aBiochemistry, general.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783319070810
830		0	_aSpringer Theses, Recognizing Outstanding Ph.D. Research, _x2190-5053
856	4	0	_uhttp://dx.doi.org/10.1007/978-3-319-07082-7
912			_aZDB-2-ENG
942			_cEBK
999			_c57763 _d57763