000			03876nam a22005535i 4500
001			978-1-4471-6599-6
003			DE-He213
005			20200421112235.0
007			cr nn 008mamaa
008			141010s2015 xxk| s |||| 0|eng d
020			_a9781447165996 _9978-1-4471-6599-6
024	7		_a10.1007/978-1-4471-6599-6 _2doi
050		4	_aTA349-359
072		7	_aTGMD _2bicssc
072		7	_aTEC009070 _2bisacsh
072		7	_aSCI041000 _2bisacsh
082	0	4	_a620.1 _223
245	1	0	_aMultiscale Modeling in Biomechanics and Mechanobiology _h[electronic resource] / _cedited by Suvranu De, Wonmuk Hwang, Ellen Kuhl.
264		1	_aLondon : _bSpringer London : _bImprint: Springer, _c2015.
300			_aVIII, 286 p. 84 illus., 63 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_a1. Proteins: Ssp DnaE Intein -- 2. Protein Crystals: Molecular to Continuum Level Models based on Crystal Plasticity Theory -- 3. Molecular Motors: Cooperative Phenomena of Multiple Molecular Motors. - 4. Biofilament dynamics: Line-to-rod-level Descriptions -- 5. Primary Cilia: Multi-Scale Structures that integrate Biomechanics and Mechanobiology. - 6. Biological Scaffolding: Reduced-Order Network Models -- 7. Transport phenomena: Computational models for convective and diffusive transport in capillaries and tissue -- 8.Tendons and ligaments: Current state and future directions. - 9. Arteries: Mechanics, Mechanobiology, and the Need for a New Class of Models -- 10. Mitral Valves: A computational framework. - 11. Biological systems: Multiscale modeling based on Mixture Theory.
520			_aPresenting a state-of-the-art overview of theoretical and computational models that link characteristic biomechanical phenomena, this book provides guidelines and examples for creating multiscale models in representative systems and organisms. It develops the reader's understanding of and intuition for multiscale phenomena in biomechanics and mechanobiology, and introduces a mathematical framework and computational techniques paramount to creating predictive multiscale models.   Biomechanics involves the study of the interactions of physical forces with biological systems at all scales - including molecular, cellular, tissue and organ scales. The emerging field of mechanobiology focuses on the way that cells produce and respond to mechanical forces - bridging the science of mechanics with the disciplines of genetics and molecular biology. Linking disparate spatial and temporal scales using computational techniques is emerging as a key concept in investigating some of the complex problems underlying these disciplines.   Providing an invaluable field manual for graduate students and researchers of theoretical and computational modelling in biology, this book is also intended for readers interested in biomedical engineering, applied mechanics and mathematical biology.
650		0	_aEngineering.
650		0	_aBioinformatics.
650		0	_aComputational biology.
650		0	_aBiomathematics.
650		0	_aMechanics.
650		0	_aMechanics, Applied.
650		0	_aBiomedical engineering.
650	1	4	_aEngineering.
650	2	4	_aTheoretical and Applied Mechanics.
650	2	4	_aBiomedical Engineering.
650	2	4	_aMathematical and Computational Biology.
650	2	4	_aComputer Appl. in Life Sciences.
700	1		_aDe, Suvranu. _eeditor.
700	1		_aHwang, Wonmuk. _eeditor.
700	1		_aKuhl, Ellen. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781447165989
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-4471-6599-6
912			_aZDB-2-ENG
942			_cEBK
999			_c58232 _d58232