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008 200929s2020 xx o 000 0 eng d
040 _aOCoLC-P
_beng
_cOCoLC-P
020 _a9780429795749
_q(electronic bk.)
020 _a0429795742
_q(electronic bk.)
020 _a9780429438004
_q(electronic bk.)
020 _a0429438001
_q(electronic bk.)
020 _a9780429795732
_q(electronic bk. : EPUB)
020 _a0429795734
_q(electronic bk. : EPUB)
020 _a9780429795725
_q(electronic bk. : Mobipocket)
020 _a0429795726
_q(electronic bk. : Mobipocket)
020 _z1138345245
020 _z9781138345249
035 _a(OCoLC)1198017380
_z(OCoLC)1197868601
035 _a(OCoLC-P)1198017380
050 4 _aRA1231.M52
072 7 _aHEA
_x048000
_2bisacsh
072 7 _aMED
_x096000
_2bisacsh
072 7 _aSCI
_x026000
_2bisacsh
072 7 _aPSBT
_2bicssc
082 0 4 _a615.9/253
_223
245 0 0 _aMETAL TOXICOLOGY HANDBOOK
_h[electronic resource].
260 _a[S.l.] :
_bCRC PRESS,
_c2020.
300 _a1 online resource
505 0 _aCover -- Half Title -- Title Page -- Copyright Page -- Dedication -- Table of Contents -- Preface -- Editors -- Contributors -- Part I: Introduction: Metals, Metalloids, Redox Biology, and Neurodegeneration -- Chapter 1 Role of Metals and Metalloids in Redox Biology -- 1.1 Introduction -- 1.2 Iron -- 1.3 Lead -- 1.4 Mercury -- 1.5 Cadmium -- 1.6 Chromium -- 1.7 Manganese -- 1.8 Copper -- 1.9 Zinc -- 1.10 Arsenic -- 1.11 Concluding Remarks -- References -- Chapter 2 Role of Metals in Neurodegeneration -- 2.1 Introduction -- 2.2 Essential Metals -- 2.2.1 Copper -- 2.2.2 Iron -- 2.2.3 Manganese
505 8 _a2.2.4 Zinc -- 2.3 Non-Essential Metals -- 2.3.1 Aluminum -- 2.3.2 Arsenic -- 2.3.3 Cadmium -- 2.3.4 Lead -- 2.3.5 Methylmercury -- 2.3.6 Thallium -- 2.4 Neurotoxicity Induced by Metal Mixture -- 2.5 Metal-Induced Neurotoxicity and Treatment -- 2.6 Conclusions and Future Directions -- References -- Part II: Pathology of Metal Toxicity -- Chapter 3 Pathological Manifestations and Mechanisms of Metal Toxicity -- 3.1 General Introduction -- 3.2 Central and Peripheral Nervous System -- 3.2.1 Introduction -- 3.2.2 Aluminum -- 3.2.3 Arsenic -- 3.2.4 Lead -- 3.2.5 Manganese -- 3.2.6 Mercury
505 8 _a3.2.7 Cadmium -- 3.3 Immune System -- 3.3.1 Introduction -- 3.3.2 Arsenic -- 3.3.2.1 Immunosuppression -- 3.3.2.2 Immunomodulation -- 3.3.3 Cadmium -- 3.3.3.1 Immunosuppression -- 3.3.3.2 Immunomodulation -- 3.3.4 Mercury -- 3.3.4.1 Immunosuppression -- 3.3.4.2 Immunomodulation -- 3.3.4.3 Sensitization and Autoimmunity -- 3.3.5 Beryllium -- 3.3.5.1 Sensitization -- 3.3.6 Nickel -- 3.3.6.1 Immunosuppression -- 3.3.6.2 Sensitization -- 3.3.7 Lead -- 3.3.7.1 Immunosuppression -- 3.3.7.2 Autoimmunity -- 3.4 Reproductive System -- 3.4.1 Introduction -- 3.4.2 Lead -- 3.4.3 Cadmium -- 3.4.4 Vanadium
505 8 _a3.4.5 Gallium and Indium -- 3.5 Liver -- 3.5.1 Introduction -- 3.5.2 Arsenic -- 3.5.3 Cadmium -- 3.5.4 Copper -- 3.5.5 Iron -- 3.6 Kidney -- 3.6.1 Introduction -- 3.6.2 Cadmium -- 3.6.3 Mercury -- 3.6.4 Lead -- 3.6.5 Uranium -- 3.7 Summary and Conclusions -- References -- Chapter 4 An Overview of Heavy Metal Research in Traditional Chinese Medicine -- 4.1 Introduction -- 4.2 Research Progress of Heavy Metal in TCM -- 4.2.1 Analytical Methods for Heavy Metal Detection in TCM -- 4.2.2 External and Internal Reasons for Heavy Metal Contamination of TCM
505 8 _a4.3 International Standards Regarding Heavy Metals and Their Safety Limit in TCM -- 4.4 Discussion and Conclusion -- References -- Part III: Mechanisms of Restoring Metabolic Homeostasis -- Chapter 5 Development and Utilization of a Novel Prodosomed-Electrolyte and Phytochemical Formulation Technology to Restore Metabolic Homeostasis -- 5.1 Introduction -- 5.2 Sources of Dietary Electrolytes -- 5.3 Electrolyte Balance and Imbalance: Physiological Consequences -- 5.4 Key Physiological Functions of Diverse Electrolytes -- 5.4.1 Nervous System -- 5.4.2 Muscle Functioning -- 5.4.3 Hydration Status
520 _aHeavy metals and metalloids, singly or in combination, induce toxic manifestations either through acute or chronic pathology. In particular, long-term chronic exposure to diverse heavy metals and metalloids to humans and animals can lead to numerous physical, muscular, neurological, nephrological, and diverse degenerative diseases and dysfunctions, including multiple sclerosis, muscular dystrophy, Parkinson's and Alzheimer's diseases, cardiovascular disorders, and several others. Recognized heavy metals such as lead, mercury, arsenic, cadmium, thallium, and hexavalent chromium are known for enormous toxicity. The immediate vital signs of acute heavy metal exposure include nausea, vomiting, diarrhea, and acute abdominal pain. Mercury has been identified as the most toxic heavy metal, and mercury poisoning is known as acrodynia or pink disease. Similarly, lead, another toxic heavy metal, was at one time an integral part of painting. Metal Toxicology Handbook further explains and discusses the varying attributes of metals, discussing toxicity, safety, and proper human utilization of metals. Beginning with a broad overview of metals, metalloids, redox biology, and neurodegeneration and going further into the roles, benefits, and toxicity of metals with each section, the text contains 28 chapters from eminent researchers and scientists in their respective fields and is a must-have for anyone researching the potential toxicity in metals. Key Features Discusses the pathology of metal toxicity Highlights the benefits of metals Explains the mechanism and salient features of restoring metabolic homeostasis Highlights dose-dependent beneficial and adverse effects of vanadium safety and toxicity The initial introductory section provides a broad overview of metals, metalloids, redox biology, and neurodegeneration. The second section discusses the pathology of metal toxicity in two chapters, while the third section highlights the mechanism and salient features of restoring metabolic homeostasis in two chapters. The fourth section demonstrates the aspect of radionuclides toxicity. In a change of pace, the fifth section discusses the benefits of metals in four chapters. The sixth section, titled "Toxic Manifestations by Diverse Heavy Metals and Metalloids," provides fourteen chapters that discuss the toxicological mechanism and manifestation of individual metals. The editors have crafted a commentary titled "A Treatise on Metal Toxicity" and summarized a vivid scenario of metal toxicity and its consequences.
588 _aOCLC-licensed vendor bibliographic record.
650 0 _aMetals
_xToxicology.
_912467
650 0 _aOrgans (Anatomy)
_912468
650 7 _aMEDICAL / Toxicology
_2bisacsh
_910713
650 7 _aSCIENCE / Environmental Science
_2bisacsh
_95087
856 4 0 _3Taylor & Francis
_uhttps://www.taylorfrancis.com/books/9780429438004
856 4 2 _3OCLC metadata license agreement
_uhttp://www.oclc.org/content/dam/oclc/forms/terms/vbrl-201703.pdf
942 _cEBK
999 _c70226
_d70226