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020 _a9789811025297
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024 7 _a10.1007/978-981-10-2529-7
_2doi
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082 0 4 _a610.28
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100 1 _aLaurent, Sophie.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
_948741
245 1 0 _aMRI Contrast Agents
_h[electronic resource] :
_bFrom Molecules to Particles /
_cby Sophie Laurent, Céline Henoumont, Dimitri Stanicki, Sébastien Boutry, Estelle Lipani, Sarah Belaid, Robert N. Muller, Luce Vander Elst.
250 _a1st ed. 2017.
264 1 _aSingapore :
_bSpringer Nature Singapore :
_bImprint: Springer,
_c2017.
300 _aVII, 125 p. 63 illus., 44 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
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490 1 _aNanotheranostics,
_x2197-6759
505 0 _aNanomaterials in medicine -- Magnetic properties (diamagnetism, paramagnetism, ferromagnetism, ferrimagnetism, antiferromagnetism, superparamagnetism) -- Imaging probes -- Magnetic resonance imaging (MRI) -- Bases of MRI -- MRI contrast agents -- Paramagnetic gadolinium complexes -- Superparamagnetic iron oxide nanoparticles -- Synthesis of magnetic nanoparticles -- Stabilization of magnetic nanoparticles -- Physico-chemical characterization of nanoparticles -- MRI applications -- Conclusions.
520 _aThis book describes the multiple aspects of (i) preparation of the magnetic core, (ii) the stabilization with different coatings, (iii) the physico-chemical characterization and (iv) the vectorization to obtain specific nanosystems. Several bio-applications are also presented in this book. In the early days of Magnetic Resonance Imaging (MRI), paramagnetic ions were proposed as contrast agents to enhance the diagnostic quality of MR images. Since then, academic and industrial efforts have been devoted to the development of new and more efficient molecular, supramolecular and nanoparticular systems. Old concepts and theories, like paramagnetic relaxation, were revisited and exploited, leading to new scientific tracks. With their high relaxivity payload, the superparamagnetic nanoparticles are very appealing in the context of molecular imaging but challenges are still numerous: absence of toxicity, specificity, ability to cross the biological barriers, etc. .
650 0 _aBiomedical engineering.
_93292
650 0 _aBiomaterials.
_916365
650 0 _aMicrotechnology.
_928219
650 0 _aMicroelectromechanical systems.
_96063
650 0 _aMedicine—Research.
_936667
650 0 _aBiology—Research.
_936668
650 0 _aMedical physics.
_94451
650 1 4 _aBiomedical Engineering and Bioengineering.
_931842
650 2 4 _aBiomaterials.
_916365
650 2 4 _aMicrosystems and MEMS.
_948742
650 2 4 _aBiomedical Research.
_936670
650 2 4 _aMedical Physics.
_94451
700 1 _aHenoumont, Céline.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
_948743
700 1 _aStanicki, Dimitri.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
_948744
700 1 _aBoutry, Sébastien.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
_948745
700 1 _aLipani, Estelle.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
_948746
700 1 _aBelaid, Sarah.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
_948747
700 1 _aMuller, Robert N.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
_948748
700 1 _aVander Elst, Luce.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
_948749
710 2 _aSpringerLink (Online service)
_948750
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
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776 0 8 _iPrinted edition:
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830 0 _aNanotheranostics,
_x2197-6759
_948751
856 4 0 _uhttps://doi.org/10.1007/978-981-10-2529-7
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