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020 _a9789811080753
_9978-981-10-8075-3
024 7 _a10.1007/978-981-10-8075-3
_2doi
050 4 _aTA349-359
072 7 _aTGMD
_2bicssc
072 7 _aSCI096000
_2bisacsh
072 7 _aTGMD
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082 0 4 _a620.105
_223
100 1 _aLacroix, Damien.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
_951183
245 1 0 _aMultiscale Mechanobiology in Tissue Engineering
_h[electronic resource] /
_cby Damien Lacroix, Marzia Brunelli, Cécile Perrault, Adrien Baldit, Maryam Shariatzadeh, Ana Campos Marin, Andre Castro, Sara Barreto.
250 _a1st ed. 2019.
264 1 _aSingapore :
_bSpringer Nature Singapore :
_bImprint: Springer,
_c2019.
300 _aXIII, 203 p. 102 illus., 82 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aFrontiers of Biomechanics,
_x2199-8523 ;
_v3
505 0 _aA review of bioreactors and mechanical stimuli -- Multiscale simulation of bioreactor design and in vitro conditions -- Mechanical stimulation in a PCL additive manufacturing scaffold -- Towards a new approach to analyse quality control and morphometric variability in a scaffold -- Computational simulation of cell seeding in a tissue engineering scaffold -- Collagen gel cell encapsulation to study mechanotransduction -- Collagen gel cell encapsulation to study the effect of fluid flow on mechanotransduction -- Computational modeling of collagen hydrogel -- Mechanical load transfer at the cellular level -- Quantification of CSK mechanics and deformation in relation to cellular functioning -- The future of tissue engineering design for bioreactor stimulation.
520 _aThis book focuses on the mechanobiological principles in tissue engineering with a particular emphasis on the multiscale aspects of the translation of mechanical forces from bioreactors down to the cellular level. The book contributes to a better understanding of the design and use of bioreactors for tissue engineering and the use of mechanical loading to optimize in vitro cell culture conditions. It covers experimental and computational approaches and the combination of both to show the benefits that computational modelling can bring to experimentalists when studying in vitro cell culture within a scaffold. With topics from multidisciplinary fields of the life sciences, medicine, and engineering, this work provides a novel approach to the use of engineering tools for the optimization of biological processes and its application to regenerative medicine. The volume is a valuable resource for researchers and graduate students studying mechanobiology and tissue engineering. For undergraduate students it also provides deep insight into tissue engineering and its use in the design of bioreactors. The book is supplemented with extensive references for all chapters to help the reader to progress through the study of each topic.
650 0 _aMechanics, Applied.
_93253
650 0 _aSolids.
_93750
650 0 _aBiomedical engineering.
_93292
650 0 _aRegenerative medicine.
_915361
650 0 _aBiophysics.
_94093
650 1 4 _aSolid Mechanics.
_931612
650 2 4 _aBiomedical Engineering and Bioengineering.
_931842
650 2 4 _aRegenerative Medicine and Tissue Engineering.
_932772
650 2 4 _aBiophysics.
_94093
700 1 _aBrunelli, Marzia.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
_951184
700 1 _aPerrault, Cécile.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
_951185
700 1 _aBaldit, Adrien.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
_951186
700 1 _aShariatzadeh, Maryam.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
_951187
700 1 _aCampos Marin, Ana.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
_951188
700 1 _aCastro, Andre.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
_951189
700 1 _aBarreto, Sara.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
_951190
710 2 _aSpringerLink (Online service)
_951191
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9789811080746
776 0 8 _iPrinted edition:
_z9789811080760
776 0 8 _iPrinted edition:
_z9789811340567
830 0 _aFrontiers of Biomechanics,
_x2199-8523 ;
_v3
_951192
856 4 0 _uhttps://doi.org/10.1007/978-981-10-8075-3
912 _aZDB-2-ENG
912 _aZDB-2-SXE
942 _cEBK
999 _c78727
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