000			02565nam a2200361 i 4500
001			CR9781139049627
003			UkCbUP
005			20230516164926.0
006			m|||||o||d||||||||
007			cr||||||||||||
008			110307s2012||||enk o ||1 0|eng|d
020			_a9781139049627 (ebook)
020			_z9780521769501 (hardback)
040			_aUkCbUP _beng _erda _cUkCbUP
050	0	0	_aQP301 _b.V53 2012
082	0	0	_a612.7 _223
100	1		_aViceconti, Marco, _eauthor. _968242
245	1	0	_aMultiscale modeling of the skeletal system / _cMarco Viceconti.
264		1	_aCambridge : _bCambridge University Press, _c2012.
300			_a1 online resource (viii, 211 pages) : _bdigital, PDF file(s).
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
500			_aTitle from publisher's bibliographic system (viewed on 05 Oct 2015).
505	0		_aMethodological aspects -- The body level -- Organ level : the bones -- Tissue level : mineralized extracellular matrix -- Cellular level : cell-matrix interaction -- Applications of multiscale modeling -- Multiscale modeling.
520			_aIntegrative approaches to biomedical research promise to advance our understanding of the human body and physiopathology of diseases. In this book, the author focuses on the skeletal system, demonstrating how multiscale modeling can determine the relationship between bone mechanics and disease. Introductory chapters explain the concept of integrative research, what a model is, predictive modeling, and the computational methods used throughout the book. Starting with whole body anatomy, physiology and modeling, subsequent chapters scale down from bone and tissue levels to the cellular level, where the modeling of mechanobiological processes is addressed. Finally, the principles are applied to address truly complex, multiscale interactions. Special attention is given to real-world clinical applications: one in pediatric skeletal oncology and one on the prediction of fracture risks in osteoporotic patients. This book has wide interdisciplinary appeal and is a valuable resource for researchers in mechanical and biomedical engineering, quantitative physiology and computational biology.
650		0	_aMusculoskeletal system _xMathematical models. _968243
650		0	_aMultiscale modeling. _93979
650		0	_aBones _xMechanical properties _xMathematical models. _968244
776	0	8	_iPrint version: _z9780521769501
856	4	0	_uhttps://doi.org/10.1017/CBO9781139049627
942			_cEBK
999			_c82304 _d82304