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020 _a9783031016295
_9978-3-031-01629-5
024 7 _a10.1007/978-3-031-01629-5
_2doi
050 4 _aT1-995
072 7 _aTBC
_2bicssc
072 7 _aTEC000000
_2bisacsh
072 7 _aTBC
_2thema
082 0 4 _a620
_223
100 1 _aBattail, Gerard.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
_979735
245 1 3 _aAn Outline of Informational Genetics
_h[electronic resource] /
_cby Gerard Battail.
250 _a1st ed. 2008.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2008.
300 _aXVII, 191 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aSynthesis Lectures on Biomedical Engineering,
_x1930-0336
505 0 _aForeword -- Introduction -- A Brief Overview of Molecular Genetics -- An Overview of Information Theory -- More on Molecular Genetics -- More on Information Theory -- An Outline of Error-Correcting Codes -- DNA is an Ephemeral Memory -- A Toy Living World -- Subsidiary Hypothesis, Nested System -- Soft Codes -- Biological Reality Conforms to the Hypotheses -- Identification of Genomic Codes -- Conclusion and Perspectives.
520 _aHeredity performs literal communication of immensely long genomes through immensely long time intervals. Genomes nevertheless incur sporadic errors referred to as mutations which have significant and often dramatic effects, after a time interval as short as a human life. How can faithfulness at a very large timescale and unfaithfulness at a very short one be conciliated? The engineering problem of literal communication has been completely solved during the second half of the XX-th century. Originating in 1948 from Claude Shannon's seminal work, information theory provided means to measure information quantities and proved that communication is possible through an unreliable channel (by means left unspecified) up to a sharp limit referred to as its capacity, beyond which communication becomes impossible. The quest for engineering means of reliable communication, named error-correcting codes, did not succeed in closely approaching capacity until 1993 when Claude Berrou and Alain Glavieuxinvented turbocodes. By now, the electronic devices which invaded our daily lives (e.g., CD, DVD, mobile phone, digital television) could not work without highly efficient error-correcting codes. Reliable communication through unreliable channels up to the limit of what is theoretically possible has become a practical reality: an outstanding achievement, however little publicized. As an engineering problem that nature solved aeons ago, heredity is relevant to information theory. The capacity of DNA is easily shown to vanish exponentially fast, which entails that error-correcting codes must be used to regenerate genomes so as to faithfully transmit the hereditary message. Moreover, assuming that such codes exist explains basic and conspicuous features of the living world, e.g., the existence of discrete species and their hierarchical taxonomy, the necessity of successive generations and even the trend of evolution towards increasingly complex beings. Providing geneticists with an introduction to information theory and error-correcting codes as necessary tools of hereditary communication is the primary goal of this book. Some biological consequences of their use are also discussed, and guesses about hypothesized genomic codes are presented. Another goal is prompting communication engineers to get interested in genetics and biology, thereby broadening their horizon far beyond the technological field, and learning from the most outstanding engineer: Nature. Table of Contents: Foreword / Introduction / A Brief Overview of Molecular Genetics / An Overview of Information Theory / More on Molecular Genetics / More on Information Theory / An Outline of Error-Correcting Codes / DNA is an Ephemeral Memory / A Toy Living World / Subsidiary Hypothesis, Nested System / Soft Codes / Biological Reality Conforms to the Hypotheses / Identification of Genomic Codes / Conclusion and Perspectives.
650 0 _aEngineering.
_99405
650 0 _aBiophysics.
_94093
650 0 _aBiomedical engineering.
_93292
650 1 4 _aTechnology and Engineering.
_979736
650 2 4 _aBiophysics.
_94093
650 2 4 _aBiomedical Engineering and Bioengineering.
_931842
710 2 _aSpringerLink (Online service)
_979737
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9783031005015
776 0 8 _iPrinted edition:
_z9783031027574
830 0 _aSynthesis Lectures on Biomedical Engineering,
_x1930-0336
_979738
856 4 0 _uhttps://doi.org/10.1007/978-3-031-01629-5
912 _aZDB-2-SXSC
942 _cEBK
999 _c84837
_d84837