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020 _a9783031025693
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024 7 _a10.1007/978-3-031-02569-3
_2doi
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072 7 _aPB
_2bicssc
072 7 _aMAT000000
_2bisacsh
072 7 _aPB
_2thema
082 0 4 _a510
_223
100 1 _aKuldell, Natalie.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
_981519
245 1 0 _aGenome Refactoring
_h[electronic resource] /
_cby Natalie Kuldell, Neal Lerner.
250 _a1st ed. 2009.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2009.
300 _aXII, 66 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aSynthesis Lectures on Synthetic Biology,
_x2151-0016
505 0 _aTools for Genome Engineering and Synthetic Biology -- Bacteriophage as Templates for Refactoring -- Methods/Teaching Protocols for M13 Reengineering -- Writing and Speaking as Biological Engineers -- Summary and Future Directions -- Appendix A -- Appendix B -- Appendix C.
520 _aThe science of biology celebrates the discovery and understanding of biological systems that already exist in nature. In parallel, the engineering of biology must learn how to make use of our understanding of the natural world to design and build new useful biological systems. ""Synthetic biology"" represents one example of recent work to engineer biological systems. This emerging field aims to replace the ad hoc process of assembling biological systems by primarily developing tools to assemble reliable-but-complex living organisms from standard components that can later be reused in new combination. The focus of this book is ""genome refactoring,"" one of several approaches to manage the complexity of a biological system in which the goal is to redesign the genetic elements that encode a living form--preserving the function of that form but encoding it with a genome far easier to study and extend. This book presents genome refactoring in two ways: as an important aspect of the emerging field of synthetic biology and as a powerful teaching tool to train would be professionals in the subject. Chapters focus on the overarching goals of synthetic biology and their alignment with the motivations and achievements in genome engineering; the engineering frameworks of refactoring, including genome synthesis, standardization of biological parts, and abstraction; a detailed description of the bacteriophages that have been refactored up to this point; and the methods of refactoring and contexts for that work drawn from the bacteriophage M13. Overall, these examples offer readers the potential for synthetic biology and the areas in need of further research. If successful, synthetic biology and genome refactoring could address any number of persistent societal needs, including sustainable energy, affordable and effective medicine, and green manufacturing practices. Table of Contents:Tools for Genome Engineering and Synthetic Biology / Bacteriophage as Templates for Refactoring / Methods/Teaching Protocols for M13 Reengineering / Writing and Speaking as Biological Engineers / Summary and Future Directions / Appendix A / Appendix B / Appendix C.
650 0 _aMathematics.
_911584
650 0 _aEngineering.
_99405
650 0 _aBiotechnology.
_97533
650 0 _aBiology
_xTechnique.
_981520
650 1 4 _aMathematics.
_911584
650 2 4 _aTechnology and Engineering.
_981521
650 2 4 _aBiotechnology.
_97533
650 2 4 _aBiological Techniques.
_943339
700 1 _aLerner, Neal.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
_923687
710 2 _aSpringerLink (Online service)
_981522
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9783031014413
776 0 8 _iPrinted edition:
_z9783031036972
830 0 _aSynthesis Lectures on Synthetic Biology,
_x2151-0016
_981523
856 4 0 _uhttps://doi.org/10.1007/978-3-031-02569-3
912 _aZDB-2-SXSC
942 _cEBK
999 _c85190
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