000 03864nam a22005535i 4500
001 978-3-031-02578-5
003 DE-He213
005 20240730164005.0
007 cr nn 008mamaa
008 220601s2010 sz | s |||| 0|eng d
020 _a9783031025785
_9978-3-031-02578-5
024 7 _a10.1007/978-3-031-02578-5
_2doi
050 4 _aQH505
072 7 _aPHVN
_2bicssc
072 7 _aSCI009000
_2bisacsh
072 7 _aPHVN
_2thema
082 0 4 _a571.4
_223
100 1 _aAthanasiou, Kyriacos.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
_981534
245 1 0 _aArticular Cartilage Tissue Engineering
_h[electronic resource] /
_cby Kyriacos Athanasiou, Eric M. Darling, Jerry C. Hu.
250 _a1st ed. 2010.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2010.
300 _aX, 174 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aSynthesis Lectures on Tissue Engineering,
_x1944-0308
505 0 _aHyaline Articular Cartilage -- Cartilage Aging and Pathology -- In Vitro -- Bioreactors -- Future Directions.
520 _aCartilage injuries in children and adolescents are increasingly observed, with roughly 20% of knee injuries in adolescents requiring surgery. In the US alone, costs of osteoarthritis (OA) are in excess of $65 billion per year (both medical costs and lost wages). Comorbidities are common with OA and are also costly to manage. Articular cartilage's low friction and high capacity to bear load makes it critical in the movement of one bone against another, and its lack of a sustained natural healing response has necessitated a plethora of therapies. Tissue engineering is an emerging technology at the threshold of translation to clinical use. Replacement cartilage can be constructed in the laboratory to recapitulate the functional requirements of native tissues. This book outlines the biomechanical and biochemical characteristics of articular cartilage in both normal and pathological states, through development and aging. It also provides a historical perspective of past and current cartilage treatments and previous tissue engineering efforts. Methods and standards for evaluating the function of engineered tissues are discussed, and current cartilage products are presented with an analysis on the United States Food and Drug Administration regulatory pathways that products must follow to market. This book was written to serve as a reference for researchers seeking to learn about articular cartilage, for undergraduate and graduate level courses, and as a compendium of articular cartilage tissue engineering design criteria. Table of Contents: Hyaline Articular Cartilage / Cartilage Aging and Pathology / In Vitro / Bioreactors / Future Directions.
650 0 _aBiophysics.
_94093
650 0 _aMaterials science.
_95803
650 0 _aMaterials.
_97549
650 0 _aBiomedical engineering.
_93292
650 1 4 _aBiophysics.
_94093
650 2 4 _aMaterials Science.
_95803
650 2 4 _aMaterials Engineering.
_932311
650 2 4 _aBiomedical Engineering and Bioengineering.
_931842
700 1 _aDarling, Eric M.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
_981535
700 1 _aHu, Jerry C.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
_981536
710 2 _aSpringerLink (Online service)
_981537
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9783031014505
776 0 8 _iPrinted edition:
_z9783031037061
830 0 _aSynthesis Lectures on Tissue Engineering,
_x1944-0308
_981538
856 4 0 _uhttps://doi.org/10.1007/978-3-031-02578-5
912 _aZDB-2-SXSC
942 _cEBK
999 _c85193
_d85193