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020 _a9783031791772
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024 7 _a10.1007/978-3-031-79177-2
_2doi
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100 1 _aMirzaei, Hamed.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
_986100
245 1 0 _aExosomes and MicroRNAs in Biomedical Science
_h[electronic resource] /
_cby Hamed Mirzaei, Neda Rahimian, Hamid Reza Mirzaei, Javid Sadri Nahand, Michael R. Hamblin.
250 _a1st ed. 2022.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2022.
300 _aXIV, 161 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
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_2rdacarrier
347 _atext file
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490 1 _aSynthesis Lectures on Biomedical Engineering,
_x1930-0336
520 _aMicroRNAs (miRNAs) are a member of the family of non-coding RNA molecules, and consist of small conserved sequences between 19-25 nucleotides in length that are responsible for regulating many cellular functions by affecting a wide range of messenger RNAs in a sequence specific manner. Fundamental biological processes like cell proliferation and growth, stress resistance, tumorigenesis, fat metabolism, and neural development have all been shown to be governed by miRNAs. miRNAs carry out the post-transcriptional silencing of gene expression via targeting the 30-untranslated region (UTR) of the complementary mRNA sequence. The dysregulation of the expression levels of various miRNAs is typical of tumor cells, and has been associated with tumor progression and poor prognosis. Many miRNAs are up-regulated in cancer, where they can silence tumor suppressor genes such as apoptosis and immune response associated genes. Therefore, it is possible to profile the expression levels of miRNAs as biomarkers, in order to diagnose cancer and noncancerous diseases. Moreover, cancer detection in the early stages is crucial in clinical situations. Characterization of miRNAs in serum, plasma, and other bodily fluids, and understanding their stability against RNase degradation, is important to assess their suitability as biomarkers and diagnostic tools. Exosomes play an important role in inter-cellular communications, and these nanosized particles have various functions in diverse physiological pathways, in normal as well as abnormal cells. Exosomes can carry diverse cargos such as mRNAs, miRNAs, and proteins that transfer information between donor and recipient cells. Furthermore, uptake of exosomes and their cargos may promote or suppress various molecular and cellular pathways, which alter the cellular behavior. Many reports have discussed the role of exosomes released from cancer cells on the progression of cancer at various stages. Exosomes and their cargos may affect the growth ofthe tumor, metastasis, drug resistance, immune system function, as well as angiogenesis. Therefore, exosomes have been explored as diagnostic biomarkers in many cancers. Moreover, exosomes can be used as biological vehicles to deliver different drugs and agents like doxorubicin (DOX), miRNAs, and siRNAs. The present book covers the role of exosomes and micro-RNAs in the pathogenesis and treatment of various diseases.
650 0 _aEngineering.
_99405
650 0 _aBioengineering.
_93883
650 0 _aBiomedical engineering.
_93292
650 1 4 _aTechnology and Engineering.
_986101
650 2 4 _aBiological and Physical Engineering.
_986102
650 2 4 _aBiomedical Engineering and Bioengineering.
_931842
700 1 _aRahimian, Neda.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
_986103
700 1 _aMirzaei, Hamid Reza.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
_986104
700 1 _aNahand, Javid Sadri.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
_986107
700 1 _aHamblin, Michael R.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
_918994
710 2 _aSpringerLink (Online service)
_986109
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9783031791826
776 0 8 _iPrinted edition:
_z9783031791727
776 0 8 _iPrinted edition:
_z9783031791871
830 0 _aSynthesis Lectures on Biomedical Engineering,
_x1930-0336
_986111
856 4 0 _uhttps://doi.org/10.1007/978-3-031-79177-2
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