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001 978-3-031-02582-2
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007 cr nn 008mamaa
008 220601s2012 sz | s |||| 0|eng d
020 _a9783031025822
_9978-3-031-02582-2
024 7 _a10.1007/978-3-031-02582-2
_2doi
050 4 _aQH505
072 7 _aPHVN
_2bicssc
072 7 _aSCI009000
_2bisacsh
072 7 _aPHVN
_2thema
082 0 4 _a571.4
_223
100 1 _aWilkinson, Ashley E.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
_987313
245 1 0 _aCentral Nervous System Tissue Engineering
_h[electronic resource] :
_bCurrent Considerations and Strategies /
_cby Ashley E. Wilkinson, Aleesha M. McCormick, Nic D. Leipzig.
250 _a1st ed. 2012.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2012.
300 _aVIII, 112 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aSynthesis Lectures on Tissue Engineering,
_x1944-0308
505 0 _aIntroduction -- Anatomy of the CNS and Progression of Neurological Damage -- Biomaterials for Scaffold Preparation -- Cell Sources for CNS TE -- Stimulation and Guidance -- Concluding Remarks.
520 _aCombating neural degeneration from injury or disease is extremely difficult in the brain and spinal cord, i.e. central nervous system (CNS). Unlike the peripheral nerves, CNS neurons are bombarded by physical and chemical restrictions that prevent proper healing and restoration of function. The CNS is vital to bodily function, and loss of any part of it can severely and permanently alter a person's quality of life. Tissue engineering could offer much needed solutions to regenerate or replace damaged CNS tissue. This review will discuss current CNS tissue engineering approaches integrating scaffolds, cells and stimulation techniques. Hydrogels are commonly used CNS tissue engineering scaffolds to stimulate and enhance regeneration, but fiber meshes and other porous structures show specific utility depending on application. CNS relevant cell sources have focused on implantation of exogenous cells or stimulation of endogenous populations. Somatic cells of the CNS are rarely utilized for tissue engineering; however, glial cells of the peripheral nervous system (PNS) may be used to myelinate and protect spinal cord damage. Pluripotent and multipotent stem cells offer alternative cell sources due to continuing advancements in identification and differentiation of these cells. Finally, physical, chemical, and electrical guidance cues are extremely important to neural cells, serving important roles in development and adulthood. These guidance cues are being integrated into tissue engineering approaches. Of particular interest is the inclusion of cues to guide stem cells to differentiate into CNS cell types, as well to guide neuron targeting. This review should provide the reader with a broad understanding of CNS tissue engineering challenges and tactics, with the goal of fostering the future development of biologically inspired designs. Table of Contents: Introduction / Anatomy of the CNS and Progression of Neurological Damage / Biomaterials for Scaffold Preparation / Cell Sources for CNS TE / Stimulation and Guidance / Concluding Remarks.
650 0 _aBiophysics.
_94093
650 0 _aMaterials science.
_95803
650 0 _aMaterials.
_97549
650 0 _aBiomedical engineering.
_93292
650 1 4 _aBiophysics.
_94093
650 2 4 _aMaterials Science.
_95803
650 2 4 _aMaterials Engineering.
_932311
650 2 4 _aBiomedical Engineering and Bioengineering.
_931842
700 1 _aMcCormick, Aleesha M.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
_987317
700 1 _aLeipzig, Nic D.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
_987318
710 2 _aSpringerLink (Online service)
_987320
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9783031014543
776 0 8 _iPrinted edition:
_z9783031037108
830 0 _aSynthesis Lectures on Tissue Engineering,
_x1944-0308
_987321
856 4 0 _uhttps://doi.org/10.1007/978-3-031-02582-2
912 _aZDB-2-SXSC
942 _cEBK
999 _c86080
_d86080