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020 _a9783031025839
_9978-3-031-02583-9
024 7 _a10.1007/978-3-031-02583-9
_2doi
050 4 _aQH505
072 7 _aPHVN
_2bicssc
072 7 _aSCI009000
_2bisacsh
072 7 _aPHVN
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082 0 4 _a571.4
_223
100 1 _aBueno, Ericka.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
_987323
245 1 0 _aBiologic Foundations for Skeletal Tissue Engineering
_h[electronic resource] /
_cby Ericka Bueno, Julie Glowacki.
250 _a1st ed. 2011.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2011.
300 _aIX, 215 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aSynthesis Lectures on Tissue Engineering,
_x1944-0308
505 0 _aIntroduction -- Structure and Function of Bone and Cartilage Tissue -- Development -- Responses to Injury and Grafting -- Clinical Applications for Skeletal Tissue Engineering -- Animal Models -- Tissue Engineering Principles for Bone and Cartilage -- Perspectives.
520 _aTissue engineering research for bone and joint applications entails multidisciplinary teams bringing together the needed expertise in anatomy, biology, biochemistry, pathophysiology, materials science, biomechanics, fluidics, and clinical and veterinary orthopedics. It is the goal of this volume to provide students and investigators who are entering this exciting area with an understanding of the biologic foundations necessary to appreciate the problems in bone and cartilage that may benefit from innovative tissue engineering approaches. This volume includes state-of-the-art information about bone and cartilage physiology at the levels of cell and molecular biology, tissue structure, developmental processes, their metabolic and structural functions, responses to injury, mechanisms of post-natal healing and graft incorporation, the many congenital and acquired disorders, effects of aging, and current clinical standards of care. It reviews the strengths and limitations of various experimental animal models, sources of cells, composition and design of scaffolds, activities of growth factors and genes to enhance histogenesis, and the need for new materials in the context of cell-based and cell-free tissue engineering. These building blocks constitute the dynamic environments in which innovative approaches are needed for addressing debilitating disorders of the skeleton. It is likely that a single tactic will not be sufficient for different applications because of variations in the systemic and local environments. The realizations that tissue regeneration is complex and dynamic underscore the continuing need for innovative multidisciplinary investigations, with an eye to simple and safe therapies for disabled patients. Table of Contents: Introduction / Structure and Function of Bone and Cartilage Tissue / Development / Responses to Injury and Grafting / Clinical Applications for Skeletal Tissue Engineering / Animal Models / Tissue Engineering Principles for Bone and Cartilage / Perspectives.
650 0 _aBiophysics.
_94093
650 0 _aMaterials science.
_95803
650 0 _aMaterials.
_97549
650 0 _aBiomedical engineering.
_93292
650 1 4 _aBiophysics.
_94093
650 2 4 _aMaterials Science.
_95803
650 2 4 _aMaterials Engineering.
_932311
650 2 4 _aBiomedical Engineering and Bioengineering.
_931842
700 1 _aGlowacki, Julie.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
_987326
710 2 _aSpringerLink (Online service)
_987328
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9783031014550
776 0 8 _iPrinted edition:
_z9783031037115
830 0 _aSynthesis Lectures on Tissue Engineering,
_x1944-0308
_987329
856 4 0 _uhttps://doi.org/10.1007/978-3-031-02583-9
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942 _cEBK
999 _c86081
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