000 04824nam a22005535i 4500
001 978-3-031-02584-6
003 DE-He213
005 20240730165055.0
007 cr nn 008mamaa
008 220601s2012 sz | s |||| 0|eng d
020 _a9783031025846
_9978-3-031-02584-6
024 7 _a10.1007/978-3-031-02584-6
_2doi
050 4 _aQH505
072 7 _aPHVN
_2bicssc
072 7 _aSCI009000
_2bisacsh
072 7 _aPHVN
_2thema
082 0 4 _a571.4
_223
100 1 _aCohen, Smadar.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
_987332
245 1 0 _aCardiac Tissue Engineering
_h[electronic resource] /
_cby Smadar Cohen, Emil Ruvinov, Yulia Sapir.
250 _a1st ed. 2012.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2012.
300 _aXIV, 190 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aSynthesis Lectures on Tissue Engineering,
_x1944-0308
505 0 _aIntroduction -- The Heart: Structure, Cardiovascular Diseases, and Regeneration -- Cell Sources for Cardiac Tissue Engineering -- Biomaterials: Polymers, Scaffolds, and Basic Design Criteria -- Biomaterials as Vehicles for Stem Cell Delivery and Retention in the Infarct -- Bioengineering of Cardiac Patches, In Vitro -- Perfusion Bioreactors and Stimulation Patterns in Cardiac Tissue Engineering -- Vascularization of Cardiac Patches -- Acellular Biomaterials for Cardiac Repair -- Biomaterial-based Controlled Delivery of Bioactive Molecules for Myocardial Regeneration.
520 _aCardiac tissue engineering aims at repairing damaged heart muscle and producing human cardiac tissues for application in drug toxicity studies. This book offers a comprehensive overview of the cardiac tissue engineering strategies, including presenting and discussing the various concepts in use, research directions and applications. Essential basic information on the major components in cardiac tissue engineering, namely cell sources and biomaterials, is firstly presented to the readers, followed by a detailed description of their implementation in different strategies, broadly divided to cellular and acellular ones. In cellular approaches, the biomaterials are used to increase cell retention after implantation or as scaffolds when bioengineering the cardiac patch, in vitro. In acellular approaches, the biomaterials are used as ECM replacement for damaged cardiac ECM after MI, or, in combination with growth factors, the biomaterials assume an additional function as a depot for prolonged factor activity for the effective recruitment of repairing cells. The book also presents technological innovations aimed to improve the quality of the cardiac patches, such as bioreactor applications, stimulation patterns and prevascularization. This book could be of interest not only from an educational perspective (i.e. for graduate students), but also for researchers and medical professionals, to offer them fresh views on novel and powerful treatment strategies. We hope that the reader will find a broad spectrum of ideas and possibilities described in this book both interesting and convincing. Table of Contents: Introduction / The Heart: Structure, Cardiovascular Diseases, and Regeneration / Cell Sources for Cardiac Tissue Engineering / Biomaterials: Polymers, Scaffolds, and Basic Design Criteria / Biomaterials as Vehicles for Stem Cell Delivery and Retention in the Infarct / Bioengineering of Cardiac Patches, In Vitro / Perfusion Bioreactors and Stimulation Patterns in Cardiac Tissue Engineering / Vascularization of Cardiac Patches / Acellular Biomaterials for Cardiac Repair / Biomaterial-based Controlled Delivery of Bioactive Molecules for Myocardial Regeneration.
650 0 _aBiophysics.
_94093
650 0 _aMaterials science.
_95803
650 0 _aMaterials.
_97549
650 0 _aBiomedical engineering.
_93292
650 1 4 _aBiophysics.
_94093
650 2 4 _aMaterials Science.
_95803
650 2 4 _aMaterials Engineering.
_932311
650 2 4 _aBiomedical Engineering and Bioengineering.
_931842
700 1 _aRuvinov, Emil.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
_987336
700 1 _aSapir, Yulia.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
_987337
710 2 _aSpringerLink (Online service)
_987340
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9783031014567
776 0 8 _iPrinted edition:
_z9783031037122
830 0 _aSynthesis Lectures on Tissue Engineering,
_x1944-0308
_987341
856 4 0 _uhttps://doi.org/10.1007/978-3-031-02584-6
912 _aZDB-2-SXSC
942 _cEBK
999 _c86083
_d86083