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020 _a9783031025808
_9978-3-031-02580-8
024 7 _a10.1007/978-3-031-02580-8
_2doi
050 4 _aQH505
072 7 _aPHVN
_2bicssc
072 7 _aSCI009000
_2bisacsh
072 7 _aPHVN
_2thema
082 0 4 _a571.4
_223
100 1 _aGrad, Sibylle.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
_988019
245 1 0 _aCells and Biomaterials for Intervertebral Disc Regeneration
_h[electronic resource] /
_cby Sibylle Grad, Mauro Alini, David Eglin, Daisuke Sakai, Joji Mochida, Sunil Mahor, Biraja Dash, Abhay Pandit, Estelle Collin.
250 _a1st ed. 2010.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2010.
300 _aVIII, 96 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aSynthesis Lectures on Tissue Engineering,
_x1944-0308
520 _aDisorders related to the intervertebral disc (IVD) are common causes of morbidity and of severe life quality deterioration. IVD degeneration, although in many cases asymptomatic, is often the origin of painful neck and back diseases. In Western societies IVD related pain and disability account for enormous health care costs as a result of work absenteeism and thus lost production, disability benefits, medical and insurance expenses. Although only a small percentage of patients with disc disorders finally will undergo surgery, spinal surgery has been one of the fastest growing disciplines in the musculoskeletal field in recent years. Nevertheless, current treatment options are still a matter of controversial discussion. In particular, they hardly can restore normal spine biomechanics and prevent degeneration of adjacent tissues. While degeneration affects all areas of the IVD, the most constant and noticeable changes occur in the gel-like central part, the nucleus pulposus (NP). Recentemphasis has therefore been put in biological ways to regenerate the NP; however, there are a number of obstacles to overcome, considering the exceptional biological and biomechanical environment of this tissue. Different biological approaches such as molecular, gene, and cell based therapies have been investigated and have shown promising results in both in vitro and in vivo studies. Nonetheless, considerable hurdles still exist in their application for IVD regeneration in human patients. The choice of the cells and the choice of the cell carrier suitable for implantation pose major challenges for research and development activities. This lecture recapitulates the basics of IVD structure, function, and degeneration mechanisms. The first part reviews the recent progress in the field of disc and stem cell based regenerative approaches. In the second part, most appropriate biomaterials that have been evaluated as cell or molecule carrier to cope with degenerative disc disease are outlined. The potential and limitations of cell- and biomaterial-based treatment strategies and perspectives for future clinical applications are discussed. Table of Contents: Cell Therapy for Nucleus Pulposus Regeneration / Recent Advances in Biomaterial Based Tissue Engineering for Intervertebral Disc Regeneration.
650 0 _aBiophysics.
_94093
650 0 _aMaterials science.
_95803
650 0 _aMaterials.
_97549
650 0 _aBiomedical engineering.
_93292
650 1 4 _aBiophysics.
_94093
650 2 4 _aMaterials Science.
_95803
650 2 4 _aMaterials Engineering.
_932311
650 2 4 _aBiomedical Engineering and Bioengineering.
_931842
700 1 _aAlini, Mauro.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
_988020
700 1 _aEglin, David.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
_988022
700 1 _aSakai, Daisuke.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
_988023
700 1 _aMochida, Joji.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
_988025
700 1 _aMahor, Sunil.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
_988026
700 1 _aDash, Biraja.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
_988028
700 1 _aPandit, Abhay.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
_988030
700 1 _aCollin, Estelle.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
_988031
710 2 _aSpringerLink (Online service)
_988033
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9783031014529
776 0 8 _iPrinted edition:
_z9783031037085
830 0 _aSynthesis Lectures on Tissue Engineering,
_x1944-0308
_988035
856 4 0 _uhttps://doi.org/10.1007/978-3-031-02580-8
912 _aZDB-2-SXSC
942 _cEBK
999 _c86190
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